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7.
Contribution of Basic and Neutral N-Compounds to the Adverse Health
Effects of Ambient Aerosols
P.
Bohn, G. Matuschek
GSF–National
Research Center for Environment and Health, Institute of Ecological
Chemistry, Focus Network: Aerosols and Health, PO Box 1129, D-85764
Neuherberg, Germany
Epidemiological
studies have revealed an increasing risk to pulmonary or cardiovascular
diseases to susceptible persons exposed to increasing amounts
of ambient aerosol particles.
A
need exists to revisit fundamental concepts why and how particles
cause health effects. The identification and quantification of
known and up to now unknown organic substances on particles is
one important step on the way to solve those questions.
A
lot of health hazard research has been addressed to the volatile
and semivolatile part of the ambient aerosols. Beside these the
knowledge about more polar components which are less volatile
is still very small.
This
work is attributed to structures which can be deduced from the
wide- spread structure of PAHs in aerosols. Amino- and Cyano-PAH
as well as basic and neutral azarenes (N- substitution of one
C in aromatic core) where chosen as surrogates. Some are known
to show biotoxicity or mutagenic activity.
In
order to provide an analytical method which can be implemented
in epidemiological studies a high-throughput-LC/MS/MS-based method
was developed. Because the detection sensitivity of some 5- and
6-membered rings were low Photo-ionization as a new ionization
technique was evaluated for this group.
Sample
preparation methods were investigated for the extraction of these
components.
The
method was used to assess the atmospheric level of these compounds
on a frequented road in the north of Munich. PM 2.5 µm samples
were collected on glass-fiber filters by a high-volume Anderson
sampler.
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